Published in the Proceedings of the National Academy of Sciences in May 2022, the previous study exposed female roundworms to male pheromones, which resulted in healthier offspring. Previously, Ruvinsky's team discovered that male pheromones slowed the aging of females' egg cells. Svetlana Dzitoyeva, a postdoctoral researcher in Ruvinsky's laboratory, co-authored the paper. Erin Aprison, a research associate in Ruvinsky's laboratory, is the paper's first author. Ruvinsky is an associate research professor at Northwestern's Weinberg College of Arts and Sciences. "But the more we study the reproductive system, the better we understand it and the more opportunities we have for developing practical interventions." "There is still a great distance between this new finding and the fertility clinic," said Northwestern's Ilya Ruvinsky, who led the study. The study will be published on May 8 in the journal Developmental Biology. Under the microscope, egg cells also looked younger and healthier, appearing round and plump rather than tiny and misshapen, which is common with aging.Īstounded by the results, the researchers replicated the experiment in fruit flies - another common model organism - and the SSRIs demonstrated the same effect.Īlthough much more work is needed, the researchers say these findings provide new opportunities to explore pharmacological interventions that might combat infertility issues in humans by improving egg quality and by delaying the onset of reproductive aging. Not only did exposure to SSRIs decrease embryonic death by more than twofold, it also decreased chromosomal abnormalities in surviving offspring by more than twofold. Surprisingly, this treatment improved the quality of aging females' egg cells. In a new study, Northwestern University researchers exposed roundworms (a well-established model organism in biological research) to selective serotonin reuptake inhibitors (SSRIs), a class of drugs used for treating depression and anxiety.
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